by S. Portet, J. A. Tuszyński, C. W V Hogue and J. M. Dixon
Abstract:
Parameters characterizing elastic properties of microtubules, measured in several recent experiments, reflect an anisotropic character. We describe the microscopic dynamical properties of microtubules using a discrete model based on an appropriate lattice of dimers. Adopting a harmonic approximation for the dimer-dimer interactions and estimating the lattice elastic constants, we make predictions regarding vibration dispersion relations and vibration propagation velocities. Vibration frequencies and velocities are expressed as functions of the elastic constants and of the geometrical characteristics of the microtubules. We show that vibrations which propagate along the protofilament do so significantly faster than those along the helix.
Reference:
Elastic vibrations in seamless microtubules. (S. Portet, J. A. Tuszyński, C. W V Hogue and J. M. Dixon), In Eur Biophys J, volume 34, 2005.
Bibtex Entry:
@ARTICLE{Portet2005b,
author = {S. Portet and J. A. Tuszyński and C. W V Hogue and J. M. Dixon},
title = {Elastic vibrations in seamless microtubules.},
journal = {Eur Biophys J},
year = {2005},
volume = {34},
pages = {912--920},
number = {7},
month = {Oct},
abstract = {Parameters characterizing elastic properties of microtubules, measured
in several recent experiments, reflect an anisotropic character.
We describe the microscopic dynamical properties of microtubules
using a discrete model based on an appropriate lattice of dimers.
Adopting a harmonic approximation for the dimer-dimer interactions
and estimating the lattice elastic constants, we make predictions
regarding vibration dispersion relations and vibration propagation
velocities. Vibration frequencies and velocities are expressed as
functions of the elastic constants and of the geometrical characteristics
of the microtubules. We show that vibrations which propagate along
the protofilament do so significantly faster than those along the
helix.},
doi = {10.1007/s00249-005-0461-4},
institution = {The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600
University Avenue, Toronto, ON M5G 1X5, Canada. sportet@mshri.on.ca},
keywords = {Anisotropy; Computer Simulation; Elasticity; Microtubules, chemistry/physiology/ultrastructure;
Models, Biological; Models, Chemical; Models, Molecular; Motion;
Protein Conformation; Tubulin, chemistry/physiology/ultrastructure;
Vibration},
language = {eng},
medline-pst = {ppublish},
owner = {sportet},
pmid = {15886985},
timestamp = {2013.11.13},
url = {http://dx.doi.org/10.1007/s00249-005-0461-4}
}