@ARTICLE{Arino2013,
  author = {Arino, Julien and Madras, Neal and Portet, St\'ephanie and Sahai, Beni},
  title = {Impact of viral mutation on suppression of infection by cytotoxic T lymphocytes},
  journal = {Canadian Applied Mathematics Quarterly},
  year = {2013},
  volume = {21},
  pages = {145--181},
  number = {2},
  abstract = {We develop a deterministic model describing the
dynamics of infected cells wearing n epitopes recognizable by n
CTL clones, in which mutation can lead to the epitopes becoming
unrecognizable by their cognate CTL clone. Some mathematical
and computational analyses of the resulting large scale
system of $2^n + n$ equations are conducted. The model is used
to examine the ability of CTL response to suppress infection
in the presence of mutations. Several situations in which CTL
escape happens are identified and conditions in which infection
is controlled are also derived. The influence of the probability
of mutation is numerically investigated.}
}