Competitive interference between influenza viral strains (bibtex)
by S.M. Moghadas, C.S. Bowman, J. Arino
Abstract:
We propose a modelling framework for investigating the dynamics of competition between immunologically- related in uenza viral strains in the absence of pre-existing immunity. Assuming that the host immune system will mount partial protection (cross-immunity) against one strain by virtue of having interacted with the other through exposure, we discuss the conditions for the occurrence of two distinct waves of infection during a single epidemic episode. Numerical simulations are presented to illustrate the possibility of infection waves with respect to the protection level induced by the first strain, and the time-lag for evolving the second strain. We propose directions for future work that involves extension of the model to include vaccination.
Reference:
Competitive interference between influenza viral strains (S.M. Moghadas, C.S. Bowman, J. Arino), In Canadian Applied Mathematics Quarterly, volume 17, 2011. (Published in 2011 with 2009 date [publisher delay]. So actual reference is Vol. 17, 2009.)
Bibtex Entry:
@Article{MoghadasBowmanArino2011,
  Title                    = {{Competitive interference between influenza viral strains}},
  Author                   = {Moghadas, S.M. and Bowman, C.S. and Arino, J.},
  Journal                  = {Canadian Applied Mathematics Quarterly},
  Year                     = {2011},
  Note                     = {Published in 2011 with 2009 date [publisher delay]. So actual reference is Vol. 17, 2009.},
  Number                   = {2},
  Pages                    = {309--316},
  Volume                   = {17},

  Abstract                 = {We propose a modelling framework for investigating the dynamics of competition between immunologically- related in uenza viral strains in the absence of pre-existing immunity. Assuming that the host immune system will mount partial protection (cross-immunity) against one strain by virtue of having interacted with the other through exposure, we discuss the conditions for the occurrence of two distinct waves of infection during a single epidemic episode. Numerical simulations are presented to illustrate the possibility of infection waves with respect to the protection level induced by the first strain, and the time-lag for evolving the second strain. We propose directions for future work that involves extension of the model to include vaccination.},
  Owner                    = {jarino},
  Timestamp                = {2011.01.17},
  Url                      = {http://server.math.umanitoba.ca/~jarino/papers/MoghadasBowmanArino-2009-CAMQ17.pdf}
}
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